Thomas J. Meade Professor

Research Statement

The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.

Selected Publications

  • Rotz MW, Manus LM, Mastarone DJ, Eckermann AL, Meade TJ, Modular Gadolinium(III) Complexes For Facile Labeling of Macromolecules and Nanomaterials. Inorganic Syntheses (2013) In press
  • Eckermann AL, Mastarone DJ, Meade TJ., (2013) The chemistry of multimodal imaging with nanoparticles Nicholas Long and Wing-Tak Wong, editors. In: The Chemistry of Molecular Imaging. Wiley Publishing. (2013) in press 
  • Matosziuk L, Holbrook RJ, Manus LM, Heffern MA, Ratner M, Meade TJ. Rational Design of [Co(acacen)L2]+ Inhibitors of Biological Activity. Dalton Transactions. (2013) Jan 22. 
  • Manus L, Holbrook R, Atesin T, Heffern MC, Harney A, Eckermann A, Meade TJ., Axial Ligand Exchange of N—herteocyclic Cobalt(III) Schiff Base Complexes: Molecular Structure and NMR Solution Dynamics. Inorganic Chemistry (2013), 52(2), 1069-1076.
  • Heffern MC, Yamamoto N, Holbrook RJ, Eckermann AL, Meade TJ. Cobalt Derivatives as Promising Therapeutic Agents. Curr Op Chem Bio. (2012) Dec 24. pii: S1367-5931(12)00150-0. 
  • Velasco, Pauline T.; Heffern, Marie C.; Sebollela, Adriano; Popova, Izolda A.; Lacor, Pascale N.; Lee, Kevin B.; Sun, Xiaoxia; Tiano, Benjamin N.; Viola, Kirsten L.; Eckermann, Amanda L.; Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies ACS Chemical Neuroscience, 2012, Nov 21;3(11):972-81. 
  • Rose S, Eren M, Murphy S, Zhang H, Thaxton CS, Chowaniec J, Waters EA, Meade TJ, Vaughan DE, Perlman., A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis. Ann Rheum Dis. 2013, Jan;72(1):89-95. 
  • Manus, Lisa M.; Strauch, Renee C.; Hung, Andy H.; Eckermann, Amanda L.; Meade, Thomas J.,Analytical Methods for Characterizing Magnetic Resonance Probes Analytical Chemistry, 2012, 84(15), 6278-6287.
  • Matosziuk, L.M., Harney, A.S., MacRenaris, K.W., Meade, T.J., Synthesis, Characterization, and in Vitro Testing of a Bacteria-Targeted MR Contrast Agent., European Journal of Inorganic Chemistry, (2012), 2012(12), 2099-2107. 
  • Harney AS, Sole LB, Meade TJ. Kinetics and Thermodynamics of an irreversible CO(III) Schiff base complex protein inhibitor with matrix metalloproteinase-2. Journal of Biological Inorganic Chemistry, 2012, Aug; 17(6):853-60. 
  • Waters EA, Meade TJ. Targeted Agents for Wall Imaging. Magnetic Resonance Angiography, J.C. Carr and T.J. Carroll, Eds.; Springer Science Business Media, 2012, LLC 15, 199-210.
  • Hurtado, Ryan; Harney, Allison; Holbrook, R.; Heffern, M., Holmgren, R.; Meade, T.J., Specific Inhibition of the transcription factor Ci by a Cobalt(III)-Schiff base-DNA conjugate Molecular Pharmaceutics, Mol Pharm 2012; 9(2):325-333. 
  • Schultz-Sikma, EA., Meade, TJ. Supramolecular Chemistry in Biological Imaging In Vivo. In Supramolecular Chemistry: From Molecules to Nanomaterials; P. A. Gale and J. W. Steed, Eds.; John Wiley & Sons, Ltd.,(2012), 4, 1857-1876.
  • Harney AS, Meade TJ, and LaBonne C. Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate. PLoS One 2012, 7(2):e32318. 
  • Feld DJ, Hsu H, Eckermann, AL, Meade, TJ. Trinuclear Ruthenium Clusters as Bivalent Electrochemical Probes for Ligand-Receptor Binding Interactions., Langmuir 2012 Jan 10; 28(1):939-949. 
  • Song Y, Meade TJ, Astashkin AV, Klein EL, Enemark JH, Raitsimring A. Pulsed Dipolar Spectroscopy Distance Measurements in Biomacromolecules Labeled with Gd(III) Markers, Journal of Magnetic Resonance, 2011 May; 210 (1), 59-68, 2011.
  • Feld DJ, Hsu H, Eckermann, AL, Meade, TJ. Trinuclear Ruthenium Clusters as Bivalent Electrochemical Probes for Ligand-Receptor Binding Interactions., Langmuir 2012 Jan 10; 28(1):939-949. 
  • Sukerkar P, MacRenaris KW, Burdette JE, Meade TJ A Steroid-Conjugated Magnetic Resonance Probe Enhances Contrast in Progesterone Receptor Expressing Organs and Tumors in Vivo. Molecular Parmaceutics. 2011. 8, 1390-1400. 
  • Strauch,C.; Mastarone, DJ.; Sukerkar, PA.; Song; Ipsaro, J J.; Meade, TJ. Reporter Protein-Targeted Probes for Magnetic Resonance Imaging, Journal of the American Chemical Society, 2011 Oct 19;133(41):16346-9. 
  • Sweeney CM, Nehl CL, Hasan W, Liang T, Eckermann AL, Meade TJ, and Odom TW, Three-Channel Spectrometer for Wide-Field Imaging of Anisotropic Plasmonic Nanoparticles, The Journal of Physical Chemistry, 2011, 115(32), 15933-15937. 
  • Sukekar P, MacRenairs KW, Townsend, TR, Ahmed RA, Burdette JE and Meade J, Synthesis and Biological Evaluations of Water-Soluble Progesterone-conjugated Probes for Magnetic Resonance Imaging of Hormone Related Cancers, Bioconjugate Chemistry, 2011 Nov 16; 22(11):2304-16. PMCID: PMC3218219

Selected Honors/Awards

  • Fellow of the World Molecular Imaging Society (2012)
  • Fellow of the American Chemical Society (2011)
  • Society for Molecular Imaging Annual Exceptional Achievement Award
  • Musselman Award for Visiting Scientist (2010)
  • Illinois Biotechnology Industry Organization (iBIO) iCON Innovator Award (2009)
  • Miller Professor, University of California Berkeley (2009)
  • Northwestern University Excellence in Teaching Award (2008)
  • William Beaumont Award: Wayne County Medical Society (2007)
  • Allen & Constance Ford Distinguished Award, CaseWestern ReserveUniversity (2006)
  • Eileen Foell Chair in Cancer Research, Northwestern University, (2005)
  • Elected President – Society of Molecular Imaging - Membership>1,000 Chair (2005)
  • Committee- Imaging in 2020 IV, (2005)
  • FMC Award - Princeton University, (2004)
  • Elkin Distinguished Investigators Cancer Lecturer, Emory University (2003)
  • Neuroscience Award Lecture, Society for Neuro-Oncology (November 2002)
  • National Academy of Engineering Lecturer, Cleveland, Ohio, (2000)
  • Pendergast Lecturer, University of Pennsylvania (1999)
  • American College of Neuropharmacology Lecturer (1999)
  • Caltech Grubstakes Award (1996, 1998)