Thomas J. Meade Professor

Research Statement

The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.

Selected Publications

  • Eckermann AL, Mastarone DJ, Meade TJ. (2014) “The chemistry of multimodal imaging with nanoparticles.” Nicholas Long and Wing-Tak Wong, editors. In: The Chemistry of Molecular Imaging. Wiley Publishing. (2014) In press
  • Townsend TR, Moyle-Heyrman G, Sukerkar PA, MacRenaris KW, Burdette JE, Meade TJ. “Progesterone-targeted magnetic resonance imaging probes.” Bioconjugate Chemistry. 2014 Aug 20;25(8):1428-1437
  • Hung AH, Holbrook RJ, Rotz MW, Glasscock CJ , Mansukhani ND, MacRenaris KW, Manus LM, Duch MC, Dam KT, Hersam MC, and Meade TJ. “Graphene Oxide Enhances Cellular Delivery of Hydrophilic Small Molecules by Co-incubation.” (2014) ACS Nano, Article ASAP Epub: September 16, 2014
  • Preslar AT, Parigi G, McClendon MT, Sefick SS, Moyer TJ, Haney C, Waters EA, MacRenaris KW, Luchinat C, Stupp SI, Meade TJ. “Gd(III) Labeled Peptide Nanofibers for Reporting on Biomaterial Localization In Vivo.” ACS Nano (2014), 8 (7), pp 7325–7332
  • Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WB, Eckermann AE, Meade TJ. "Modulation of Amyloid-β Aggregation by Histidine-coordinating Cobalt(III) Schiff Base Complexes." Chem Bio Chem (2014) Jul 21;15(11):1584-9.
  • Heffern MC, Matosziuk LM, Meade TJ. “Lanthanide Probes for Bioresponsive Imaging.” Chem. Rev., (2014) Apr 23;114(8):4496-539
  • Carney CE, MacRenaris KW, Mastarone DJ, Kasjanski DR, Hung AH, Meade, TJ. “Cell Labeling Via Membrane-Anchored Lipophilic MR Contrast Agents.” Bioconjugate Chemistry (2014) May 21;25(5):945-54.
  • Trivedi ER, Ma Z, Waters EA, MacRenaris KW, Subramanian R, Barrett AGM, Meade TJ, Hoffman BM. (2013) “Synthesis and Characterization of a Porphyrazine – Gd(III) MRI Contrast Agent and in vivo Imaging of a Breast Cancer Xenograft Model.” Contrast Media and Molecular Imaging (2014), Jul; 9(4):313-22.
  • Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI,Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, Stegh AH. “RNAi-based spherical nucleic acid nanoparticle conjugates as a novel therapeutic paradigm for Glioblastoma.” Science Trans. Med., (2013), Oct 30;5(209):209ra152.
  • Chapman S, Dobrovolskaia M, Farahani K, Goodwin A, Joshie A, Hakho L, Meade TJ, Pomper M, Ptak K, Rao J, Singh R, Sridhar S, Stern S, Wang A, Weaver JB, Woloschak G, Yang L. "Nanoparticles for cancer imaging: The good, the bad, and the promise.” Nano Today (2013), 8(5), 454-460.
  • Hong BJ, Swindell EP, MacRenaris KW, Hankins PL, Chipre AJ, Mastarone DJ, Ahn RW, Meade TJ, O'Halloran TV, Nguyen SBT. “pH-Responsive Theranostic Polymer-Caged Nanobins: Enhanced Cytotoxicity and T1 MRI Contrast by Her2 Targeting.” Particle & Particle Systems Characterization (2013), 30(9), 770-774.
  • Ke C, Strutt NL, Li H, Hou X, Hartlieb KJ, McGonigal PR, Ma Z, Iehl J, Stern CL, Cheng C, Zhu Z, Vermeulen NA, Meade TJ, Botros YY, and Stoddart JF. “Pillar[5]arene as a Co-Factor in Templating Rotaxane Formation.” JACS (2013), 135(45), 17019-17030.
  • Edwards, DT, Ma Z, Meade TJ, Goldfarb D, Han S, Sherwin MS. “Extending the distance range accessed with continuous wave EPR with Gd3+ spin probes at high magnetic fields.” Physical Chemistry Chemical Physics (2013), 15(27), 11313-11326.
  • Ahrens MJ, Bertin PA, Vonesh EF, Meade, TJ, Catalona WJ, Georganopoulou D. “PSA enzymatic activity: A new biomarker for assessing prostate cancer aggressiveness.” From Prostate (Hoboken, NJ, United States) (2013), 73(16), 1731-1737.
  • Crans DC, Meade TJ. “Preface for the Forum on Metals in Medicine and Health: New Opportunities and Approaches to Improving Health.” Inorganic Chemistry (2013), 52(21), 12181-12183.
  • Meade TJ. “Weak interactions: a facile methodology for multiarray electronic detection of proteins.” American Chemical Society, Division of Energy & Fuels (2013), 58(1), 1270
  • Heffern MC, Kurutz J, Meade TJ. (2013) “Spectroscopic Elucidation of the Inhibitory Mechanism of Cys2His2 Zinc Finger Transcription Factors by Cobalt(III) Schiff Base Complexes.” Chem Eur J. (2013), 19(50), 17043-17053.
  • Edwards DT, Ma Z, Meade TJ, Goldfarb D, Han S, Sherwin MS. “Extending the distance range accessed with continuous wave EPR with Gd3+ spin probes at high magnetic fields.” Physical Chemistry Chemical Physics (2013), 15(27), 11313-11326.
  • Raitsimring A, Astashkin AV, Enemark JH, Kaminker I, Goldfarb D, Walter ED, Song Y, Meade TJ. “Optimization of Pulsed-DEER Measurements for Gd-Based Labels: Choice of Operational Frequencies, Pulse Durations and Positions, and Temperature.” Applied Magnetic Resonance (2013), 44(6), 649-670.
  • Matosziuk L, Holbrook RJ, Manus LM, Heffern MA, Ratner M, Meade TJ. “Rational Design of [Co(acacen)L2]+ Inhibitors of Biological Activity.” Dalton Transactions. (2013) Mar 21;42(11):4002-12
  • Manus LM, Holbrook RJ, Atesin T, Heffern MC, Harney A, Eckermann A, Meade TJ. “Axial Ligand Exchange of N—herteocyclic Cobalt(III) Schiff Base Complexes: Molecular Structure and NMR Solution Dynamics.” Inorganic Chemistry (2013), 52(2), 1069-1076.
  • Matosziuk LM, Holbrook RJ, Manus LM, Heffern MC, Ratner MA, Meade, TJ. “Rational Design of [Co(acacen)L2]+ Inhibitors of Protein Function.” Dalton Trans. (2013), 42(11):4002-12
  • Rose S, Eren M, Murphy S, Zhang H, Thaxton CS, Chowaniec J, Waters EA, Meade TJ, Vaughan DE, Perlman., “A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis.” Ann Rheum Dis. (2013), Jan;72(1):89-95.
  • Peterson MD, Holbrook RJ, Meade TJ, Weiss EA. “Photoinduced Electron Transfer from PbS Quantum Dots to Cobalt(III) Schiff Base Complexes: Light Activation of a Protein Inhibitor,” Journal of the American Chemical Society (2013), 135(35), 13162-13167.
  • Hung, AH; Duch, MC; Parigi, G; Rotz, MW; Manus, LM; Mastarone, DJ; Dam, KT; Gits, CC; MacRenaris, KW; Luchinat, C; Hersam, MC; Meade, TJ. “Mechanisms of Gadographene-Mediated Proton Spin Relaxation.” Journal of Physical Chemistry C Nanomater Interfaces (2013), Aug 8;117(31), 16263-16273.

Selected Honors/Awards

  • Hill Lecturer, Duke University (2014)
  • Catalyst Award, Northwestern University and the City of Evanston (2014)
  • Fellow of the World Molecular Imaging Society (2012)
  • Fellow of the American Chemical Society (2011)
  • Society for Molecular Imaging Annual Exceptional Achievement Award
  • Musselman Award for Visiting Scientist (2010)
  • Illinois Biotechnology Industry Organization (iBIO) iCON Innovator Award (2009)
  • Miller Professor, University of California Berkeley (2009)
  • Northwestern University Excellence in Teaching Award (2008)
  • William Beaumont Award: Wayne County Medical Society (2007)
  • Allen & Constance Ford Distinguished Award, CaseWestern ReserveUniversity (2006)
  • Eileen Foell Chair in Cancer Research, Northwestern University, (2005)
  • Elected President – Society of Molecular Imaging - Membership>1,000 Chair (2005)
  • Committee- Imaging in 2020 IV, (2005)
  • FMC Award - Princeton University, (2004)
  • Elkin Distinguished Investigators Cancer Lecturer, Emory University (2003)
  • Neuroscience Award Lecture, Society for Neuro-Oncology (November 2002)
  • National Academy of Engineering Lecturer, Cleveland, Ohio, (2000)
  • Pendergast Lecturer, University of Pennsylvania (1999)
  • American College of Neuropharmacology Lecturer (1999)
  • Caltech Grubstakes Award (1996, 1998)