Thomas J. Meade Professor

Research Statement

The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.

Selected Publications

  • Vistain LF, Rotz MW, Rathore R, Preslar AT, Meade TJ. “Targeted Delivery of Gold Nanoparticle Contrast Agents for Reporting Gene Detection by Magnetic Resonance Imaging” ChemComm, (2015), DOI: 10.1039/C5CC06565H. PMCID in process.
  • Banerjee SR, Ngen EJ, Rotz MW, Kakkad S, Lisok A, Pracitto R, Pullambhatla M, Chen Z, Shah T, Artemov D, Meade TJ, Bhujwalla ZM and Pomper MG. “Synthesis and Evaluation of GdIII-Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen” Angewandte Chemie, International Edition (2015) Epub 23 JUL 2015. PMCID in Process.
  • Heffern MC, Reichova V, Coomes J, Harney A, Bajema EA, Meade TJ. “Tuning Cobalt(III) Schiff Base Complexes as Activated Protein Inhibitors.” Inorg Chem (2015) DOI: 10.1021/acs.inorgchem.5b01415. Epub 02 SEP 2015. PMCID in Process.
  • Carney CE, MacRenaris KW, Meade TJ. “Water-Soluble Lipophilic MR Contrast Agents for Cell Membrane Labeling” Journal of Biological Inorganic Chemistry (2015) Sep;20(6):971-7. PMCID: PMC4546878
  • Vistain LF, Yamamoto N, Rathore R, Cha P, Meade TJ. “Targeted inhibition of Snail activity in breast cancer cells using a Co(III)-Ebox conjugate” ChemBioChem (2015) Aug 25. doi: 10.1002/cbic.201500289. [Epub ahead of print] PMCID in process.
  • Harrison VSR, Carney CE, Macrenaris KW, Waters EA, Meade TJ, "A Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging" J Am Chem Soc. (2015) Jul 22;137(28):9108-16. PMCID: PMC4512902
  • Carney CE, Lenov IL, Baker CJ, MacRenaris, KW, Eckermann AL, Sligar SG, Meade TJ, “Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging” Bioconj Chem (2015), May 20;26(5):899-905. PMCID: PMC4486023.
  • Holbrook RM, Weinberg D, Peterson M, Weiss E, Meade TJ, "Light-Activated Protein Inhibition through Photoinduced Electron Transfer of a Ruthenium(II)-Cobalt(III) Bimetallic Complex" JACS (2015) Mar 11;137(9):3379-85. PMCID: PMC4487626.
  • Rotz MW, Culver KSB, Parigi G, MacRenaris KW, Luchinat C, Odom TW, Meade TJ, “High Relaxivity Gd(III)-DNA Gold Nanostars: Investigation of Shape Effects on Proton Relaxation” ACS Nano. (2015) Mar 24;9(3):3385-96. PMCID:PMC4489565.
  • Raitsimring A, Dalaloyan A, Collauto A, Feintuch A, Meade TJ, Goldfarb D, “Zero Field Splitting Fluctuations Induced Phase Relaxation of Gd3+ in Frozen Solutions at Cryogenic Temperatures” Journal of Magnetic Resonance (2014) Nov;248:71-80. PMCID: PMC4495766.
  • Hung AH, Holbrook RJ, Rotz MW, Glasscock CJ, Mansukhani ND ,MacRenaris KW, Manus LM, Duch MC, Dam KT, Hersam MC, and Meade TJ, “Graphene Oxide Enhances Cellular Delivery of Hydrophilic Small Molecules by Co-incubation” ACS Nano (2014) Oct 28;8(10):10168-77 PMCID: PMC4212791.
  • Harrison VSR, Carney CE, Macrenaris KW and Meade TJ, “A Multimeric MR-optical Contrast Agent for Multimodal Imaging,” Chem. Commun., (2014), Oct 9;50(78):11469-71. PMCID: PMC4344311.
  • Preslar AT, Parigi G, McClendon MT, Sefick SS, Moyer TJ, Haney C, Waters EA, MacRenaris KW, Luchinat C, Stupp SI, Meade TJ, “Gd(III) Labeled Peptide Nanofibers for Reporting on Biomaterial Localization In Vivo.” ACS Nano (2014) Jul 22;8(7):7325-32. PMCID: PMC4216205.
  • Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WB, Eckermann AE, Meade TJ, "Modulation of Amyloid-β Aggregation by Histidine-coordinating Cobalt(III) Schiff Base Complexes" Chem Bio Chem (2014) Jul 21;15(11):1584-9. PMCID: PMC4166533.
  • Townsend TR Moyle-Heyrman G, Sukerkar PA, MacRenaris KW, Burdette JE, Meade TJ. “Progesterone-targeted Magnetic Resonance Imaging Probe Bioconjugate Chemistry. (2014) 25(8), 1428-1437. PMCID: PMC4140536.
  • Bendok BR, El Tecle NE, El Ahmadieh TY, Koht A, Gallagher TA, Parrish TB, Carroll TJ, Markl M, Sabbagha A, Dewald JPA, Meade TJ, Samson D, Batjer HH. “Advances and Innovation in Brain Arteriovenous Malformations Surgery” Neurosurgery (2014) 74:S60–S73, 2014.
  • Heffern MC, Matosziuk LM, Meade TJ. “Lanthanide Probes for Bioresponsive Imaging,” Chem. Rev. (2014), 114(8), 4496-4539. PMCID: PMC3999228.
  • Trivedi ER, Ma Z, Waters EA, MacRenaris KW, Subramanian R, Barrett AGM, Meade TJ, Hoffman BM. “Synthesis and Characterization of a Porphyrazine – Gd(III) MRI Contrast Agent and in vivo Imaging of a Breast Cancer Xenograft Model.” Contrast Media and Molecular Imaging (2014), Jul; 9(4):313-22. PMC4327828.
  • Carney CE, MacRenaris KW, Mastarone DJ, Kasjanski DR, Hung AH, Meade TJ. “Cell Labeling Via Membrane-Anchored Lipophilic MR Contrast Agents.” Bioconjugate Chemistry (2014) 25(5),945-954. PMCID: PMC4033656.
  • Eckermann AL, Mastarone DJ, Meade TJ. (2013) “Chemical strategies for the development of multimodal imaging probes using nanoparticles.” Nicholas Long and Wing-Tak Wong, editors. In: The Chemistry of Molecular Imaging. Wiley Publishing. (2014)

Selected Honors/Awards

  • Hill Lecturer, Duke University (2014)
  • Catalyst Award, Northwestern University and the City of Evanston (2014)
  • Fellow of the World Molecular Imaging Society (2012)
  • Fellow of the American Chemical Society (2011)
  • Society for Molecular Imaging Annual Exceptional Achievement Award
  • Musselman Award for Visiting Scientist (2010)
  • Illinois Biotechnology Industry Organization (iBIO) iCON Innovator Award (2009)
  • Miller Professor, University of California Berkeley (2009)
  • Northwestern University Excellence in Teaching Award (2008)
  • William Beaumont Award: Wayne County Medical Society (2007)
  • Allen & Constance Ford Distinguished Award, CaseWestern ReserveUniversity (2006)
  • Eileen Foell Chair in Cancer Research, Northwestern University, (2005)
  • Elected President – Society of Molecular Imaging - Membership>1,000 Chair (2005)
  • Committee- Imaging in 2020 IV, (2005)
  • FMC Award - Princeton University, (2004)
  • Elkin Distinguished Investigators Cancer Lecturer, Emory University (2003)
  • Neuroscience Award Lecture, Society for Neuro-Oncology (November 2002)
  • National Academy of Engineering Lecturer, Cleveland, Ohio, (2000)
  • Pendergast Lecturer, University of Pennsylvania (1999)
  • American College of Neuropharmacology Lecturer (1999)
  • Caltech Grubstakes Award (1996, 1998)