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Nathan Gianneschi



Jacob & Rosaline Cohn Professor of Chemistry

Research Statement

The Chemistry and Biology of Nanomaterials

The Gianneschi group is an interdisciplinary team of chemists, engineers, materials scientists, physicists and biologists focused on fundamental and translational research into biomaterials, polymers, nanomaterials, in situ electron microscopy, biomimicry, therapeutics, diagnostics and novel functional materials.

Selected Publications

Ungerleider, J.; Kammeyer, J.K.; Braden, R. L.; Christman, K. L.; Gianneschi, N. C. “Enzyme-Targeted Nanoparticles for Delivery to Ischemic Skeletal Muscle” Polymer Chemistry 2017.

Nguyen, M. M.; Carlini, A. S.; Chien, M. –P.; Sonnenberg, S.; Luo, C.; Braden, R. L.; Osborn, K. G.; Li, Y.; Gianneschi, N. C.*; Christman, K. L.* “Enzyme-responsive Nanoparticles for Targeted Accumulation and Prolonged Scaffold Retention in Heart Tissue After Myocardial Infarction” Adv. Mat. 2015, 27, 5547-5552. (*co-corresponding author) 

Callmann, C. E.; Barback, C. V.; Thompson, M. P.; Hall, D. J.; Mattrey, R. F.; Gianneschi, N. C. “Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors” Adv. Mat. 2015, 27, 4611-4615. PMID: 26178920. PMCID: PMC4699560

Rush, A. M.; Nelles, D. A.; Blum, A. P.; Barnhill, S. A.; Tatro, E. T.; Yeo, G. W.; Gianneschi, N. C. “Intracellular mRNA Regulation with Self-Assembled Locked Nucleic Acid Polymer Nanoparticles” J. Am. Chem. Soc. 2014, 136, 7615-7618. PMID: 24827740; PMCID: PMC4046771.

Blum, A. P.; Kammeyer, J. K.; Yin, J.; Crystal, D. T.; Rush, A. M.; Gilson, M. K. Gianneschi, N. C. “Peptides Displayed as High Density Brush Polymers Resist Proteolysis and Retain Bioactivity” J Am. Chem. Soc. 2014, 136, 15422-15437

Chien, M. –P.; Thompson, M. P.; Barback, C. V.; Hall, D. J.; Gianneschi, N. C. “Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue” Advanced Materials. 2013, 25, 3599-3604. PMID: 23712821; PMCID: PMC4108424. 

Smith, B.; Parent, L.; Overholts, A.; Beaucage, P.; Bisbey, R.; Chavez, A.; Hwang, N.; Park, C.; Evans, A.; Gianneschi, N. C.*; Dichtel, W.* “Colloidal Covalent Organic Frameworks” ACS Central Science 2017, 3, 58-65. (*co-corresponding author)

Proetto, M. T.; Anderton, C. R.; Hu, D.; Szymanski, C. J.; Zhu, Z.; Patterson, J. P.; Kammeyer, J.; Nilewski, L. G.; Rush, A. M.; Bell, N. C.; Evans, J. E.; Orr, G.; Howell, S. B. Gianneschi, N. C. “Cellular Delivery of Nanoparticles Revealed with Combined Optical and Isotopic Nanoscopy” ACS Nano 2016, 10, 4046-4054.

Patterson, J. P.; Abellan, P.; Denny, M. S.; Park, C.; Browning, N. D.; Cohen, S. M.; Evans, J. E.; Gianneschi, N. C. “Observing the Growth of Metal-Organic Frameworks by In Situ Liquid Cell TEM” J. Am. Chem. Soc. 2015, 137, 7322-7328.

Proetto, M. T.; Rush, A. M.; Chien, M. –P.; Abellan Baeza, P.; Patterson, J. P.; Thompson, M. P.; Olson, N. H.; Moore, C. E.; Rehingold, A. L.; Andolina, C.; Millston, J.; Howell, S. B.; Browning, N D.; Evans, J. E..; Gianneschi, N. C. “Dynamics of Soft  Materials Captured by Transmission Electron Microscopy” J. Am. Chem. Soc.. 2014, 136, 1162-1165. PMID: 23944844.

Biomaterials and Biomimicry:
Huang, Y.; Li, Yiwen, Hu, Z.; Yue, X.; Proetto, M. T.; Jones, Y.; Gianneschi, N. C. “Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols” ACS Central Science 2017, 3, 564-569.

Li, Y.; Xie, Y.; Wang, Z.; Zang, N.; Carniato, F.; Huang, Y.; Andolina, C. M.; Parent, L. R.; Ditri, T. B.; Walter, E. D.; Botta, M.; Rinehart, J. D.*; Gianneschi, N. C.* “Structure and Function of Iron-loaded Synthetic Melanin” ACS Nano 2016, 10,10186-10194  (*co-corresponding author).

Xiao, M.; Li, Y.; Allen, M.; Deheyn, D.; Yue, X.; Zhao, J.; Gianneschi, N. C.* Shawkey, M.;* Dhinojwala, A.* "Bioinspired Structural Colors Produced via Self-Assembly of Synthetic Melanin Nanoparticles" ACS Nano, 2015, 9, 5454-5460 (*co-corresponding author).

Polymer Chemistry and Soft Matter:
Carlini, A. S.; Adamiak, L.; Gianneschi, N. C. “Biosynthetic Polymers as Functional Materials” Macromolecules 2016, 49, 4379-4394.

Barnhill, S. A.; Bell, N. C.; Patterson, J. P.; Olds, D. P.; Gianneschi, N. C. "Phase Diagrams of Polynorbornene Amphiphilic Block Copolymers in Solution" Macromolecules 2015, 48, 1152-1161

James, C. R.; Rush, A. M.; Insley, T.; Vukovic, L.; Kral, P.; Gianneschi, N. C. “Poly(oligonucleotide)” J. Am. Chem. Soc. 2014, 136, 11216-11219

Ku, T.-H.; Chien, M.-P.; Thompson, M. P.; Sinkovits, R. S.; Olson, N. H; Baker, T. S.; Gianneschi, N. C. “Controlling and Switching the Morphology of Micellar Nanoparticles with Enzymes” J. Am. Chem. Soc. 2011, 133, 8392-8395

Chien, M. –P.; Rush, A. M.; Thompson, M. P. Gianneschi, N. C. “Programmable Shape-Shifting Micelles” Angew. Chem. Int. Ed., 2010, 49, 5076-5080

Selected Honors and Awards

  • 2017    Finalist, Blavatnik Young Scientist Award
  • 2016    Tianfu Distinguished Lecturer in Polymer Science and Engineering, Sichuan University
  • 2016    Fellow of the Royal Society of Chemistry
  • 2015    Outstanding Young Scientist Award, ACS Applied Materials & Interfaces, PAT 2015
  • 2014    UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring
  • 2013    Kavli Fellow of the National Academy of Sciences
  • 2012    NIH Director’s Transformative Research Award
  • 2012    Alfred P. Sloan Foundation Fellow
  • 2011    NIH Director’s New Innovator Award
  • 2011    UC San Diego Panhellenic Outstanding Professor Award
  • 2009    Presidential Early Career Award for Scientists and Engineers (PECASE) – DOD AFOSR
  • 2008    Camille & Henry Dreyfus Foundation New Faculty Award      
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