Alexander V. Statsyuk Assistant Professor

Research Statement

Our research interests center in the area of chemical biology. Current projects include the development of chemical tools to dissect protein phosphorylation and protein ubiquitination signaling pathways, and enzyme inhibitor discovery. Our highly interdisciplinary research group combines techniques of synthetic organic chemistry, biochemistry, cell biology and protein synthesis.

Selected Publications

Hong, C.M., Statsyuk, A.V. The Development of a One Pot, Regiocontrolled, Three-Component Reaction for the Synthesis of Thieno[2,3-c]pyrroles, Organic & Biomolecular Chemistry, 2013, 11, 2932-2935

Park, S., Ntai, I., Thomas, P., Konishcheva, E., Kelleher, N.L., Statsuk, A.V. Mechanism-Based Small Molecule Cross-Linkers of HECT E3 Ubiquitin-Ligase Substrate Pairs. Biochemistry, 2012, 51(42):8327-9

Statsuk, A.V.; Shokat, K.M., Methods in Molecular Biology, 2012, 795, 179-190

Alexander V. Statsyuk, Dustin J. Maly, Markus A. Seeliger, Miles A. Fabian, William H. Biggs, III, David J. Lockhart, Patrick P. Zarrinkar, John Kuriyan, Kevan M. Shokat. Tuning a Three-Component Reaction for Trapping Kinase Substrate Complexes. J. Am. Chem. Soc., 2008, 130, 17568 -17574.

Alexander V. Statsyuk, Ruoli Bai, Jeremy L. Baryza, Vishal A. Verma, Ernest Hamel, Paul A. Wender, Sergey A. Kozmin. Actin is the Primary Cellular Receptor of Bistramide A. Nature Chemical Biology, 2005, 1, 383-388.

Alexander V. Statsyuk, Dong Liu, Sergey A. Kozmin. Synthesis of Bistramide A. J. Am. Chem. Soc., 2004,126, 9546-9547

Selected Honors/Awards

  • 2012-2013 Northwestern University Searle Teaching Fellow
  • 2012 Pew Scholar in Biomedical Sciences