Faculty

Room: Silverman 2504
Phone: 847-491-2481
Email: tmeade@northwestern.edu
Meade Research Group Website
Division: Inorganic
Research Interests: Organic, Synthetic, Chemical Biology, Inorganic, Bioinorganic, Physical, Biophysical, Nanoscience
B.S.: Arizona State University 1980
Ph.D.: The Ohio State University 1985
Fellow in Radiology, Harvard Medical School
Postdoctoral Fellow, California Institute of Technology

Research Coordinator: Sophie Tidd

Research Statement

The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.

Selected Publications

• Feld DJ, Hsu H, Eckermann, A.L.; Meade, T.J. Trinuclear Ruthenium Clusters as Bivalent Electrochemical Probes for Ligand-Receptor Binding Interactions, Langmuir, 2012, 28(1), 939-949. PMCID: PMC3254724
  
• Matosziuk, L.M., Harney, A.S., MacRenaris, K.W., Meade, T.J., Synthesis, Characterization, and in Vitro Testing of a Bacteria-Targeted MR Contrast Agent., European Journal of Inorganic Chemistry, 2012 in press.
  
• Harney, A.S., LaBonne, C., Meade, T.J., Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate., 2012, in press.
  
• Hurtado, Ryan; Harney, Allison; Holbrook, R.; Heffern, Marie C., Holmgren, Robert J.; Meade, T.J.,
  Specific Inhibition of the transcription factor Ci by a Cobalt(III)-Schiff base-DNA conjugate Molecular Pharmaceutics, (2012), 9(2), 325-333.
  
• Harney, A.S., Sole, L.B., Meade, T.J., Kinetics and thermodynamics of irreversible inhibition of matrix metalloproteinase-2 by a Co(III) Schiff base complex. J. Inorganic Biochemistry, 2012, in press.
  
• Sweeney, CM.; Nehl, CL.; Hasan, W; Liang, T; Eckermann, AL; Meade, TJ.; Odom, TW. Three-Channel Spectrometer for Wide-Field Imaging of Anisotropic Plasmonic Nanoparticles, Journal of Physical Chemistry C, 2011, 115(32), 15933-15937.
  
• Sukerkar P, MacRenaris, KW, Burdette, JE, Meade TJ, A Steroid-Conjugated Magnetic Resonance Probe Enhances Contrast in Progesterone Receptor Expressing Organs and Tumors in Vivo. Molecular Pharmaceutics, 2011, 8(4), 1390-1400. PMCID: PMC3148317
  
• Mastarone DJ, Harrison VSR, Eckermann AL, Parigi G, Luchinat C, Meade TJ, A Modular System for the Synthesis of Multiplexed Magnetic Resonance Probes, Journal American Chemical Society, 2011, 133, 5329-5337. PMCID: PMC3086647
  
• Karfeld-Sulzer L, Waters EA, Kohlmeir EK, Kissler H, Zhang X, Kaufman DB, Barron AE, Meade TJ. Protein Polymer MRI Contrast Agents: Longitudinal Analysis of Biomaterials in Vivo. Magnetic Resonance in Medicine, 2011, 65(1) 200-8. PMCID: PMC2995002
  
• Sukerkar P, Rezvi U, MacRenaris K, Patel P, Wood J, Meade TJ. Polystyrene Microsphere-Ferritin Conjugates: A Robust Phantom for Correlation of Relaxivity and Size Distribution. Magnetic Resonance in Medicine, 2011, 65(2), 522-30.
  
• Schultz-Sikma, EA, Joshi, HM, Ma, Q, MacRenaris, KW.; Eckermann, AL, Dravid, VP, Meade, TJ, Probing the chemical stability of mixed ferrites: Implications for magnetic resonance contrast agent design , Chemistry of Materials, 2011, 23(10), 2657-2664. PMCID: PMC3097046
  
• Song Y, Meade TJ, Astashkin AV, Klein EL, Enemark JH, Raitsimring A. Pulsed Dipolar Spectroscopy Distance Measurements in Biomacromolecules Labeled with Gd(III) Markers, Journal of Magnetic Resonance, 210, 59-68, 2011. PMCID: PMC3081411
  
• Schultz-Sikma EA, Meade TJ, "Supramolecular Chemistry in Biological Imaging In Vivo," In Supramolecular Chemistry: From Molecules to Nanomaterials; P. A. Gale and J. W. Steed, Eds.; John Wiley & Sons, Ltd., (2011).
  
• Ahrens MJ, Bertin PA, Gaustad AG, Georganopoulou D, Wunder M, Blackburn GF, Gray HB, Meade TJ. Spectroscopic and redox properties of amine-functionalized K2[OsII(bpy)(CN)4] complexes. Dalton Transactions (2011), 40(8), 1732-1736.
  
• Strauch C, Mastarone DJ, Sukerkar PA, Song Y, Ipsaro JJ, Meade TJ. Reporter Protein-Targeted Probes for Magnetic Resonance Imaging, Journal of the American Chemical Society, 2011, 133(41), 16346-16349. PMCID: PMC3203639
  
• Sukekar P, MacRenaris KW, Townsend, TR, Ahmed RA, Burdette JE, Meade TJ, Synthesis and Biological Evaluations of Water-Soluble Progesterone-conjugated Probes for Magnetic Resonance Imaging of Hormone Related Cancers, Bioconjugate Chemistry, 2011, PMCID: PMC3218219
  
• Eckermann AL, Shaw J, Meade TJ. Kinetic Dispersion in Redox Active Dithiocarbamate Monolayers. Langmuir, 2010, 26(4), 2904-2913.
  
• Ho D, Meade TJ, Gd(III)-Nanodiamond Conjugates for MRI Contrast Enhancement. Nano Letters, 2010, 10(2), 484-489 PMCID: PMC2829273
  
• Hu F, MacRenaris K, Waters EA, Schultz-Sikma EA, Eckermann AL, Meade TJ. Highly Dispersible, Superparamagnetic Magnetite Nanoflowers for Magnetic Resonance Imaging. Chem. Comm., 2010, 46(1), 73-75.
  
• Manus L, Mastarone D, Waters EA, Zhang X, Schultz-Sikma E, MacRenaris K, Ho D, Meade TJ. Gd(III)-nanodiamond conjugates for MRI contrast enhancement. Nano Letters, 2010, 10(2), 484-489. PMC Journal – PMC2829273
  
• Trivedi ER, Harney AS, Olive MB, Podgorski I, Moin K, Sloane BF, Barrett AGM, Meade TJ, Hoffman BM. Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation. PNAS, 2010, 107(4), 1284-1288. PMCID: PMC2824358
  
• Harney AS, Meade TJ. Molecular imaging of in vivo gene expression. Future Medicinal Chemistry, 2010, 2(3), 503-519.
  
• Karfeld-Sulzer L, Waters E, Davis N, Meade TJ, Barron A. Multivalent Protein Polymer MRI Contrast Agents: Controlling Relaxivity via Modulation of Amino Acid Sequence, Biomacromolecules, 2010, 11(6), 1429-1436. PMCID: PMC2892858
  
• Eckermann AL, Meade TJ. Electrochemistry of Redox-Active Self Assembled Monolayers, Coord. Chem Rev., 2010, 254(15-16), 1769-1802. PMCID: PMC2885823
  
• Bertin, PA., Ahrens MJ, Bhavsar, K, Georganopoulou D, Wunder M, Blackburn GF, Meade, TJ, Ferrocene and Maleimide-Functionalized Disulfide Scaffolds for Self-Assembled Monolayers on Gold. Organic Letters (2010), 12(15), 3372-3375.
  
• Song Y, Zong H, Trivedi ER, Vesper BJ, Waters EA, Barrett AGM, Radosevich JA, Hoffman BM, Meade TJ,. Synthesis and Characterization of New Porphyrazine-Gd(III) Conjugates as Multimodal MR Contrast Agents. Bioconjugate Chemistry (2010), 21(12), 2267-2275.
  
• Hu F, Joshi HM, Dravid VP, Meade TJ. High-performance nanostructured MR contrast probes. Nanoscale (2010), 2(10), 1884-1891.
  
• Lee, S, Song Y, Hong BJ, MacRenaris KW, Mastarone DJ, O'Halloran TV, Meade TJ, Nguyen ST. Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release. Angewandte Chemie, International Edition (2010), 49(51), 9960-9964 PMCID: PMC3096927
  
• Potapov A, Song Y, Meade TJ, Goldfarb D, Astashki AV. Distance measurements in model Bis-Gd(III) complexes with flexible “bridge”: Emulation of biological molecules having flexible structure with Gd(III) label attached, Journal of Magnetic Resonance, 2010, 205(1), 38-49. PMCID: PMC2885582
  

Awards

• Fellow of the American Chemical Society, August 29, 2011
  
• Society for Molecular Imaging Annual Exceptional Achievement Award
  
• Musselman Award for Visiting Scientist, October 14-16, 2010
• Illinois Biotechnology Industry Organization (iBIO) iCON Innovator Award (2009)
• Miller Professor, University of California Berkeley (2009)
• Northwestern University Excellence in Teaching Award (2008)
• William Beaumont Award: Wayne County Medical Society (2007)
• Allen & Constance Ford Distinguished Award, CaseWestern ReserveUniversity (2006)
• Eileen Foell Chair in Cancer Research, Northwestern University, (2005)
• Elected President – Society of Molecular Imaging - Membership>1,000 Chair (2005)
• Committee- Imaging in 2020 IV, (2005)
• FMC Award - Princeton University, (2004)
• Elkin Distinguished Investigators Cancer Lecturer, Emory University (2003)
• Neuroscience Award Lecture, Society for Neuro-Oncology (November 2002)
• National Academy of Engineering Lecturer, Cleveland, Ohio, (2000)
• Pendergast Lecturer, University of Pennsylvania (1999)
• American College of Neuropharmacology Lecturer (1999)
• Caltech Grubstakes Award (1996, 1998)