Board of Trustees Professor of Material Science, Chemistry, and Medicine Professor of Biomedical Engineering
Director, Institute for BioNantechnology in Medicine (IBNAM)
Director, Louis A. Simpson and Kimberly K. Querrey Center for
Room: Cook 1127
Stupp Research Group Website
Research Interests: Organic, Materials, Nanotechnology, Self-Assembly, Supramolecular Chemistry, Solar Energy, Catalysis, Polymers, Biomaterials for Medicine
B.S.: University of California, Los Angeles 1972
Ph.D.: Northwestern University 1977
Program Assistant: Laura Fields
Research in the Stupp group is highly interdisciplinary, integrating chemistry, materials science, and medicine. The main interest of the group is the development of self-assembling organic materials, focusing on functions relevant to energy and medicine. The laboratory is currently interested in nanostructures and materials for solar photovoltaics and solar fuels, ferroelectrics for memories, regenerative medicine, and cancer therapies. The group has three different subgroups: self-assembly, solar systems, and biomaterials. Research includes molecular synthesis, characterization of structure, measurement of materials properties, cell biology, and in vivo studies of the efficacy of nanostructures and materials in medical applications.
The self-assembly subgroup works on programming of molecules to create functional supramolecular assemblies based on small molecules, polymers, and inorganic structures. The systems of interest at the moment include artificial cells which may have biomedical functions or serve as chemical microreactors, ferroelectric molecular assemblies based on electron transfer, and arrays of aligned nanofibers for tissue engineering of arteries. This sub-group focuses on all aspects of self-assembly including molecular synthesis, characterization of structure by electron microscopy, synchrotron small angle x-ray scattering, electron paramagnetic resonance, spectroscopic techniques, and computer simulations.
The solar fuels and photovoltaics subgroup is focused on the integration of self-assembly into solar photovoltaic devices and supramolecular catalytic systems for solar fuel production. Current targets include hybrid materials based on inorganic semiconductors and organic electronic materials, organic photovoltaic systems targeting designs for molecular recognition between electron acceptors and donors, and photosynthetic gels in which self-assembly processes optimize the function of catalysts for hydrogen production.
The biomaterials subgroup focuses on the development of bioactive materials that can signal cells for targets in regenerative medicine. The regenerative medicine targets include spinal cord injury, Parkinson's disease, heart regeneration, diabetes, bone, cartilage, and muscle. This subgroup also investigates novel cancer therapies based on supramolecular nanofibers targeting apoptosis of cells. The research includes molecular design of self-assembling nanostructures that optimize cell signaling for regeneration, mediate cell death vs. cell survival, and guide differentiation of stem cells. A developing interest is the use of supramolecular nanostructures for genetic reprogramming. In this area work has been initiated to create virus-like structures that could carry nucleic acids into cells.
Tayi, A. S.; Shveyd, A. K.; Sue, C-H.; Szarko, J. M.; Rolczynski, B. S.; Cao, D.; Kennedy, T. J.; Sarjeant, A. A.; Stern, C. L.; Paxton, W. F.; Wu, W.; Dey, S. K.; Fahrenbach, A. C.; Guest, J. R.; Mohseni, H.; Chen, L. X.; Wang, K. L.; Stoddart, J. F.; Stupp, S. I. “Room-Temperature Ferroelectricity in Supramolecular Networks of Charge-Transfer Complexes” Nature 2012, 488, 485-489.
Aida, T.; Meijer, E. W.; Stupp, S. I. “Functional Supramolecular Polymers” Science 2012, 335(6070), 813-817.
Webber, M. J.; Tongers, J.; Newcomb, C. J.; Marquardt, K-T.; Bauersachs, J.; Losordo, D. W.; Stupp, S. I. “Supramolecular Nanostructures that Mimic VEGF as a strategy for Ischemic Tissue Repair” Proc. Natl. Acad. Sci. 2011, 108(33), 13438-13443.
Shah, R. M.; Shah, N. A.; Del Rosario Lim, M. M.; Hsieh, C.; Nuber, G.; Stupp, S. I. “Supramolecular Design of Self-Assembling Nanofibers for Cartilage Regeneration” Proc. Natl. Acad. Sci. 2010, 107(8), 3293-3298.
Cui, H.; Pashuck, E. T.; Velichko, Y. S.; Weigand, S. J.; Cheetham, A. G.; Newcomb, C. J.; Stupp, S. I. "Spontaneous and X-Ray Triggered Crystallization at Long Range in Self-Assembling Filament Networks" Science 2010, 327(5965), 555-559.
Pashuck, E. T.; Cui, H.; Stupp, S. I. "Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure" J. Am. Chem. Soc. 2010, 132(17), 6041-6046.
Standley, M. S.; Toft, D. J.; Cheng, H.; Soukasene, S.; Chen J.; Raja, S. M.; Band, V.; Band, H.; Cryns, V. L.; Stupp, S. I. "Induction of Cancer Cell Death by Self-Assembling Nanostructures Incorporating a Cytotoxic Peptide" Cancer Research 2010, 70(8), 3020-3026.
Zhang, S.; Greenfield, M. A.; Mata, A.; Palmer, L. C.; Bitton, R.; Mantei, J. R.; Aparicio, C.; de la Cruz, M. O.; Stupp, S. I. "A Self-Assembly Pathway to Aligned Monodomain Gels" Nature Materials 2010, 9(7), 594-601.
Muraoka, T.; Koh, C-Y.; Cui, H.; Stupp, S. I. "Light-Triggered Bioactivity in Three Dimensions" Angew. Chem. Int. Ed. 2009, 48(32) 5946-5949.
Sofos, M.; Goldberger, J.; Stone, D. A.; Allen, J. E.; Ma, Q.; Herman, D. J.; Tsai. W-W.; Lauhon, L. J.; Stupp. S. I. "A Synergistic Assembly of Nanoscale Lamellar Photoconductor Hybrids" Nature Materials 2009, 8(1), 68-75.
Capito, R.; Azevedo, H.; Velichko, Y. R., Mata, A.; Stupp, S. I. "Self-Assembly of Large and Small Molecules Into Hierarchically Ordered Sacs and Membranes" Science 2008, 319(5871), 1812-1816.
Silva, G. A.; Czeisler, C.; Niece, K. L.; Beniash, E.; Kessler, J. A.; Stupp, S. I. "Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers" Science 2004, 303, 1352-1355.
Hartgerink, J. D.; Beniash, E.; Stupp, S. I. "Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers" Science 2001, 294 (5547), 1684-1688.
Stupp, S. I.; Le Bonheur, V.; Walker, K.; Li, L. S.; Huggins, K.; Keser, M.; Amstutz, A. "Supramolecular Materials: Self Organized Nanostructures" Science 1997, 276, 384-389.
Awards and Honors
- Centre for Nanomedicine Visiting Professorship, University of New South Wales (2013)
- International Scientific Advisory Board, Centre for Cooperative Research in Biomaterials-CIC biomaGUNE, Spain (2012)
- Ronald Breslow Award for Achievement in Biomimetic Chemistry (2012)
- Member, National Academy of Engineering (2012)
- Member, Royal Spanish Academy of Pharmacy (2012)
- Thomson Reuters Top 100 Chemists for 2000-2010 (2011)
- Honorary Doctorate, National University of Costa Rica (2011)
- Michelin Chair, Ecole Supérieure de Physique et de Chimie, Paris (2010)
- Fellow, Materials Research Society (2009)
- Israel Pollack Distinguished Lecture Series Award, Technion-Israel Institute of Technology (2009)
- Distinguished Professorship, Eindhoven University of Technology (2009)
- Honorary Doctorate for Revolutionary Research in Complex Molecular Systems, Eindhoven University of Technology (2009)
- Honorary membership, Israel Chemical Society (2009)
- International Advisory Group, Swedish Government Program on Biomaterials, Gothenburg University (2008)
- Member, Scientific Advisory Board, University of Vienna (2006)
- American Chemical Society Award in Polymer Chemistry (2005)
- Merck-Karl Pfister Visiting Professorship, Massachusetts Institute of Technology (2004)
- Fellow, World Technology Network (2003)
- Member, Scientific Advisory Board, National University of Singapore (2003)
- Member, Baxter Scientific Advisory Board (2001)
- Member, Solid State Sciences Committee, National Academy of Sciences (2001)
- Materials Research Society Medal Award (2000)
- Member, Basic Energy Sciences Advisory Committee, Department of Energy (1999)
- Fellow of American Association for the Advancement of Science (1999)
- Elected member of American Academy of Arts and Sciences (1998)
- Humboldt Award for Senior U.S. Scientists (1997)
- Joliot Curie Professorship, Ecole Supérieure de Physique et de Chimie Industrielles (1997)
- Member, Materials Panel, Air Force Scientific Advisory Board (1995)
- U.S. Department of Energy Prize for Outstanding Scientific Accomplishment in Materials Chemistry (1991)
- Exclusive consultant to 3M Company (1987)
- Xerox Faculty Award for Excellence in Engineering Research (1985)
- 3M Young Faculty Award (1981)