Faculty

 

 

Room: Silverman 3611
Phone: 847-491-6659
Email: scheidt@northwestern.edu
Scheidt Research Group Website
Division: Organic
Research Interests: Organic, Synthetic, Bio-Organic, Medicinal Chemistry, Chemical Biology, Catalysis, Materials
B.S.: University of Notre Dame 1994
Ph.D.: Indiana University 1999

Program Assistant: Nikki Piech

Research Statement

Our research focuses on two complementary areas: the discovery of new organic reactions and bioorganic chemistry. We are particularly interested in designing novel methods and strategies for the construction of complex natural products with important biological attributes. Our methodology programs encompass assembling molecules and introducing stereogenic centers using new catalytic reactions.

Selected Publications

Scheidt, K. A. "Amide Bonds Made in Reverse," Nature, News and Views, 2010, 465, 1020–1022.

Cardinal-David, B.; Raup, D. E. A; Scheidt, K. A. "Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenlates," J. Am. Chem. Soc. 2010, 132, 5345–5347

Phillips, E. M.; Roberts, J. M.; Scheidt, K. A. "Enantioselective Total Synthesis of (–)-Bakkenolides I, J, and S by Application of a Carbene-Catalyzed Desymmetrization," Org. Lett. 2010, 12, 2830–2833.

Raup, D. E. A.; Cardinal-David, B.; Holte, D.; Scheidt, K. A. "Cooperative Carbene Catalysis: A Highly Selective Route to ?-Lactams," Nature Chemistry, on line, doi:10.1038/nchem.727.

Brekan, J. A.; Reynolds, T. E; Scheidt, K. A. "Enantioselective Synthesis of Substituted Indanones from Silyloxyallenes," J. Am. Chem. Soc. 2010, 132, 1472-1473.

Phillips, E. M.; Chan, A.; Scheidt, K. A. "Discovering New Reactions with N-Heterocyclic Carbene Catalysis," Aldrichimica Acta 2009, 42, 55-66.

Kawanaka, Y.; Phillips, E. M.; Scheidt, K. A. "N-Heterocyclic Carbene-Catalyzed Enantioselective Mannich Reactions with a-Aryloxyacetaldehyde," J. Am. Chem. Soc. 2009, 131, 18028-18029.

Nibbs, A. E.; Maize, A. L.; Herter, R. M.; Scheidt, K. A. "Catalytic Asymmetric Alkylation of Substituted Isoflavanones," Org. Lett. 2009, 11, 4010–4013.

Lee, J. Y.; Roberts, J. M.; Farha, O. K.; Sarjeant, A. A.; Scheidt, K. A.; Hupp, J. T. "Synthesis and Gas Sorption Properties of a Metal-Azolium Framework Material," Inorganic Chemistry, 2009, 48, 9971-9973.

Maki, B. E.; Patterson, E. V.; Cramer, C. J.; Scheidt, K. A. "The Impact of Solvent Polarity on N-Heterocyclic Carbene-Catalyzed b-Protonations of Homoenolate Equivalents," Org. Lett. 2009, 11, 3942-3945.

Awards

• Amgen Young Investigator Award (2006)
• Boehringer-Ingelheim New Investigator in Organic Chemistry (2005)
• Abbott Laboratories New Faculty Award (2005)
• 3M Untenured Faculty Award (2005)
• Northwestern University Distiguished Teaching Award (2005)
• Faculty Honor Roll, Northwestern Student Government (2005)
• Amgen New Faculty Award (2004)
• National Science Foundation CAREER Award (2004-2009)
• Northwestern Searle Scholar (2003)
• NIH Postdoctoral Fellowship (1999)