Chemical and Biological Engineering
Room: Tech E136
Grzybowski Research Group Website
Research Interests: Life Sciences, Materials, Organic, Physical/Analytical
BS/MS: Yale University
Ph.D.: Harvard University
Organization and evolution in systems having many degrees of freedom and operating away from thermodynamic equilibrium ("complex dissipative systems," CDS) is of fundamental interest for its relevance to life and for potential technological applications. My research is devoted to rational design of dissipative self-assembling systems on scales from molecular to macroscopic, and to the development of "synthetic" strategies that would allow building "systems of systems" of increasing complexities. This experimental effort is multidisciplinary, and encompasses fields of chemistry, physics and biophysics. Engineering of CDS is accompanied by basic research in the molecular aspects of the phenomena (e.g., contact electrification and photochromism) these systems use. Theoretical analysis using both analytical and numerical techniques provides understanding of the general principles that govern non-equilibrium self-organization.
Wiles, Jason A.; Grzybowski, Bartosz A.; Winkleman, Adam; Whitesides, George M. "A tool for studying contact electrification in systems comprising metals and insulating polymers." Analytical Chemistry (2003), 75(18), 4859-4867.
Ng, Jessamine M. K.; Fuerstman, Michael J.; Grzybowski, Bartosz A.; Stone, Howard A.; Whitesides, George M. "Self-Assembly of Gears at a Fluid/Air Interface." Journal of the American Chemical Society (2003), 125(26), 7948-7958.
Grzybowski, Bartosz A.; Winkleman, Adam; Wiles, Jason A.; Brumer, Yisroel; Whitesides, George M. "Electrostatic self-assembly of macroscopic crystals using contact electrification." Nature Materials (2003), 2(4), 241-245.
Grzybowski, Bartosz A.; Wiles, Jason A.; Whitesides, George M. "Dynamic Self-Assembly of Rings of Charged Metallic Spheres." Physical Review Letters (2003), 90(8), 083903/1-083903/4.
Ostuni, Emanuele; Grzybowski, Bartosz A.; Mrksich, Milan; Roberts, Carmichael S.; Whitesides, George M. "Adsorption of proteins to hydrophobic sites on mixed self-assembled monolayers." Langmuir (2003), 19(5), 1861-1872.
Grzybowski, Bartosz A.; Whitesides, George M. "Directed dynamic self-assembly of objects rotating on two parallel fluid interfaces." Journal of Chemical Physics (2002), 116(19), 8571-8577.
Grzybowski, Bartosz A.; Ishchenko, Alexey V.; Shimada, Jun; Shakhnovich, Eugene I. "From Knowledge-Based Potentials to Combinatorial Lead Design in Silico." Accounts of Chemical Research (2002), 35(5), 261-269.