Solutions and colligative properties, chemical equilibrium, aqueous solution equilibria, chemical kinetics, metals in chemistry and biology, oxidation-reduction reactions and electrochemistry, special topics in modern chemistry. Must be taken concurrently with the Chem 142-0 laboratory course. Prerequisite: Chem 131-0 and Chem 141-0 (C- or better in both courses).Students may not start the sequence in this course. All Chemistry course sequences start in Fall Quarter.
The chemistry of polyfunctional compounds of biological and medicinal interest. Modern organic synthesis, bioorganic chemistry, and recent developments in organic chemistry. Must be taken concurrently with laboratory course Chem 230-3. No P/N registration. Prerequisite: Chem 210-2 and Chem 230-2 (C– or better in both courses).
Primarily for chemistry majors and students in ISP. Similar to 210-1,2,3 except with laboratory only in the first and second quarters. Must be taken concurrently with laboratory courses Chem 232-1, 2. Prerequisites: Chem 103-0 and Chem 123-0 *or* Chem 172-0 and Chem 182-0 *or* Chem 152-0 and Chem 162-0 *or* Chem 132-0 and Chem 142-0 (C– or better in both courses), appropriate AP credit, enrollment in ISP, or permission of department by placement exam.
An introduction to basic laboratory techniques in analytical chemistry and spectroscopy. Topics include infrared and UV-visible spectroscopy, gas and liquid chromatography, elemental and thermal analysis, simple X-ray diffraction, error analysis, and literature-searching techniques.Prerequisite: Chem 103-0 and Chem 123-0 *or* Chem 172-0 and Chem 182-0 *or* Chem 152-0 and Chem 162-0 *or* Chem 132-0 and Chem 142-0 *or* equivalent.
Topics in the physical chemistry of the environment. Taught with 406. Prerequisites: 210-3 and 230-3 or 212-3; MATH 234, 250; PHYSICS 135-1,2; or consent of instructor.
CHEM 316/415 Medicinal Chemistry: The Organic Chemistry of Drug Design and Action
Introduction to principles of drug design and mechanisms of drug action from a chemical viewpoint. Historical introduction, drug design and development, receptors, enzymes and enzyme inhibitors, DNA, drug metabolism, and prodrugs. Prerequisite: 210-3 and 230-3 or, 212-3, or consent of instructor.
CHEM 342-3 Kinetics and Statistical Thermodynamics
Chemical kinetics, including experimental techniques and theories of rate processes. Statistical mechanics, including Boltzmann distribution, partition functions, and applications to thermodynamics. Prerequisites: 342-1,2.
Gas laws and properties; kinetic theory; first, second, and third laws; phase equilibria; mixtures, phase diagrams, statistical thermodynamics, kinetics. Prerequisites: ISP enrollment; 172 and 182; MATH 281-1,2,3; or consent of department.
Advanced laboratory techniques in synthetic and analytical chemistry and spectroscopy: infrared and Raman spectroscopy, electronic spectroscopy, fast kinetics, organic and inorganic synthesis techniques in a self-guided project. Prerequisites: 342-2 or equivalent and 350-2; 342-3 or 348 co-requisite.
Practices of environmentally benign chemistry as applied to the chemical industry. Introduction to the concept and discipline of green chemistry; growth and expansion of the discipline in historical context from its origins in the early 1990s to the present. Prerequisite: 210-3 and 230-3 or 212-3 (C- or better).
The emergence of the mechanical bond during the past 25 years is giving chemistry a fillip in more ways than one. While its arrival on the scene is already impacting materials science and molecular nanotechnology, it is also providing a new lease of life to chemical synthesis where mechanical bond formation occurs as a consequence of the all-important templation orchestrated by molecular recognition and self-assembly processes. The way in which covalent bond formation activates noncovalent bonding interactions, switching on molecular recognition that leads to self-assembly and the template-directed synthesis of mechanically interlocked moleculesof which the so-called catenanes and rotaxanes may be regarded as the prototypeshas introduced a level of integration into chemical synthesis that has not previously been attained. The challenge now is to carry this level of integration beyond relatively small molecules into the realms of precisely functionalized extended molecular structures and aggregated superstructures that perform functions in a collective manner as the key sources of instruction, activation and performance in multi-component integrated devices. In this course I will propose the adoption of the term mechanostereochemistry to describe the rapidly emerging area of chemical science where components of molecules and extended structures are mechanically interlocked or sterically encumbered in such a manner that the components interact dynamically with one another as a result of a panoply of weak noncovalent bonds and/or as a consequence of dynamic coordinative or covalent bonds. Mechanostereochemistry is the stereochemistry of molecules with mechanical bonds. The practice of mechanostereochemistry can be seen to have both a creative aspect (molecular recognition, self-assembly, templation, etc.) and a functional role (relative movements of components, switching, self-energizing, etc.) associated with its territory. Both the creative aspect and the functional role are dynamic in nature and ultimately molecular in context. The conundrum facing the wider chemical community at present is to unravel how to get from relatively small, yet highly programmable molecules to contraptions and gadgets that do something useful in the real world. Suggested Reading : "Big and Little Meccano" Tetrahedron 2008, 64, 8231-8263.
CHEM 416-0 Practical Training in Chemical Biology Methods and Experimental Design
By the end of this course you will expected to have obtained a general understanding of many commonly used measurement techniques available to augment research at Northwestern. It features two weeks of classroom-based instruction on experimental design and analysis; supplemented by NIH Rigor And Reproducibility Training Modules. This overview will be followed by a combination of lectures and labs addressing a broad range of analytical techniques and imaging methods. These lessons will then be applied to inquiry-based learning in Northwestern's advanced instrumentation cores. In addition to lecture, students are expected to devise two Mini-Research Projects and will work on one of these with senior staff to apply specific services and protocols utilizing instrumentation available within Research Cores and University Centers. Students will design specific experiments in selected areas of their interest, and learn new sample preparation methods and instrumentation within one of the following areas: mass spectrometry; proteomics, in vivo and molecular imaging, small molecule synthesis and purification; high-throughput screening, x-ray crystallography, and analysis of bioelements. Material generated in the class counts for course credit will be usable in research group settings.
